• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The invention relates to oximes, in particular, a method for producing ethers of oximes (er) of a common yomuly. C AND-C (X) N-0-CH, -CH (OC) (OR), where P and R, are hydrogen or halogen; 1C and RZ,, alkylene; X is a fluorinated C-C, -aluch, used as antidotes for the phytotoxic effect of herbicides on cultivated plants. The goal is to create more active compounds of the specified class. Synthesis of EO compounds is carried out from the salt of the oxime of the general formula R, where R is indicated above; M is an alkali metal cation, and a haloacetal of the general formula H1-CH 2 -CH (OR3) (OR), where R and R are as defined above; Hal is halogen, in dimethyl sulfoxide environment at 60-70 ° C for 4 hours and 30, resistance to fungal damage is increased, the germination of weakly germinating seeds is less inhibited than the known compounds, at a flow rate of 0.4 kg / ha OE, this same antidote effect, as known cyanoxime at the rate of consumption. 1.5 kg / ha when treating plants with herbicides of the row of acetanilide. DLgo toxicity 4560 mg / kg. 14 tabl CO with
    公开号:SU1356958A3
    申请号:SU833564200
    申请日:1983-03-14
    公开日:1987-11-30
    发明作者:Мартен Анри；Фрикер Урс
    申请人:Циба-Гейги Аг (Фирма)；
    IPC主号:
    专利说明:

    The invention relates to a process for the preparation of new oxime ethers possessing antidote properties from the phytotoxic effect of herbicides on cultivated plants.
    The purpose of the invention is a method for producing new oxime ethers with higher antidote activity on cultivated plants from the phytotoxic effect of herbicides.
    In the examples that illustrate the synthesis of compounds and their anti-dry properties, the temperature is indicated in degrees Celsius, the pressure in millibars, and parts and percentages are by weight.
    Example 1o Preparation of 1- (4-chlorophenyl) -1- (1o3-dioxolan-2-yl-methoxyimino) -2,2,2-trifluoroethane.
    In a 100 MP round bottom flask with a capacity of 100 MP, 1.2 g (0.05 mol) of metallic sodium is dissolved in 50 ml of absolute ethanol and 11.2 (0.05 mol) of 1- (4-chlorophenyl) is added to the prepared solution. A) -1-hydroxyimino-2,2,2-trifluoroethane. When the addition is completed, the reaction mixture is first stirred for half an hour at room temperature, then the solvent is distilled off. 50 ml of dimethyl sulfoxide is added to the residue, and then with stirring 8.4 g (0.05 mol) of 2-bromomethyl, 3-dioxole are added, after which the reaction mixture additionally eremeshivayut for 4 hours at a mixture temperature of 60-70 C. Thereafter, the resulting slurry was cooled and poured into a mixture of ice and water. From the resulting mixture, the reaction product is extracted with chloride, methylene. The extract is dried with sodium sulfate, after which the solvent is distilled off. The oily substance colored in orange is obtained in the residue, which is distilled under high vacuum. The result is 12.5 g (80.6% of theoretical) 1- (4- chlorophenyl) -1- (1,3-dioxolan-2-yl-methoxyimino) -2,2,2-trifluoroethane in
    0
    five
    as a colorless oily substance with m, kip 105-108 ° C / 0.1 mbar
    The 1- (4-chlorophenyl) -1-oxyimino-2,2,2-trifluoroethane used as the starting material is obtained according to the following procedure.
    A mixture of 417 g (2.0 mol) of 4-xnop-W, HNY-trifluoroacetophenone, 139 g (2.0 Q mol) of hydroxylamine hydrochloride and 500 ml of pyridine is stirred for 15 hours at room temperature. After that, the pyridine is distilled off and the remaining oily product g is stirred in ice water. After extraction with methylene chloride, drying the extract with sodium sulfate and evaporating the solvent, 438 g (98% of theory) 1- (4-chlorofensch-1-OXYIMINO-2,2,2-trifluoroethane) is obtained as an oily substance.
    Example 2. Preparation of 1-phenyl-1- (1, 3-dioxolan-2-yl-methoxyimino) -2,2,2-trifluoroethane.
    In a solution prepared from 1.5 g (0.07 mol) of metallic sodium and 50 MP of absolute ethanol, 13.8 g (0.07 mol) of 1- (oxyimino) -1-phenyl-2,2,2- trifluoroethane, after which the solvent is distilled off. To a solution of the residue in 50 MP of dimethyl sulfoxide, 6.7 g (0.10 mol) of 2-bromomethyl-1,3-dioxolane are added dropwise with stirring. Upon the completion of the addition of 2-bromo: 1-methyl-1), 3-dioxolane, the reaction mixture is first stirred for 4 hours at a mixture temperature of 60-70 ° C, after which the resulting suspension is poured into a mixture of ice and water. After extraction with methylene chloride, drying the extract with sodium sulfate and distilling off the solvent, an orange-colored oily substance is obtained which is distilled under high vacuum. 15.0 g (78% of theory), 1-phenyl-1- (1, 3-dioxolane-2-yl-methoxyimino) 2,2,2-trifluoroethane with bp. 89-9 (, 1 mbar.
    Similarly, they get Compound-g, listed in Table
    0
    five
    0
    five
    0
    The biological activity of the compounds obtained by the proposed method.
    The ability of the compounds of formula (1) to protect cultured plants from the phytotoxic effect of strong herbicides can be detected by considering the following examples. In the description of the experiments, the compounds of formula (1) are referred to as antidote (antidotes).
    Example Zo Antidote action in relation to the herbicide on corn Treatment with antidote and herbicide in the form of (prepared in a container) mixture until germination.
    A mixture of the substance studied as an antidote and a herbicide is sprayed with a semper and then mixed. Immediately after this, the plastic containers (length 25 cm, width 17 cm, and height 12 cm) are filled with treated earth. Cultivated LG corn seed. 21 days after the treatment, the protective effect of the antidote is assessed in percent. For comparison, plants treated only with a herbicide and untreated (control) plants are used. A good significant protective effect was achieved when it was possible to reduce severe or moderate damage to the plants to mild reversible damage or to full compatibility.
    Table I
    25 S-ethyl dipropyl thiocarbamate (EPTP) is used as a herbicide, and 1- (4-chlorofon-1) -1- (1,3-dioxolan-2-yl-methoxyimino) -2,2, as an antidote; 2-trifluoroethane (compound 30 1).
    The results are shown in table about 2 about
    table 2
    35
    Consumption rate, kg / ha
    Protective action.
    herbicide
    antidote
    8 8 8 .8 4 4 4 4
    eight
    4 2
    4 2 1
    ABOUT
    38 .50 75 O
    50 75 75
    - Example 4. Experiment with intertidolum and herbicide on sorghum in the treatment before germination. The use of antidote by seed dressing.
    Continuation of tab.
    In another experiment, K-chloroacetyl-M-methoxymethyl-2,6-diethylaniline Alachlor was used as a hebicide, and 1- (4-chlorophenyl) -g- 1- (1, 3-dioxolan-2) as an antidote. -yl-methoxyimino) -2,2,2-trifluoro-tan (compound 1).
    The data obtained are given in table about 4,
    Table
    Example 5o Experiment with antidote and sorghum herbicide. Treatment with herbicide and antidote as a mixture before germination.
    56958
    Plastic containers (length 25 cm, width 17 cm, and height 12 cm) are filled with sandy alumina and sorghum seeds of the variety Funk G are sown. After the seeds are opened, they are sprayed onto the soil surface by spraying the mixture of the substance studied as an antidote and herbicide (peated solution) . 30 days after the treatment, the protective effect of the antidote is assessed in percent. In this case, for comparison, plants treated only
    5 herbicide, as well as untreated (control) plants,
    N-chloro-acetyl-N- (2-metaxy-1-methyl) -2-ethyl-6-methylaniline (Metolachlor) was used as a herbicide, and 1- (4-chlorophenyl) -1- ( 1,3-dioxolan-2-yl-methoxy-imino) -2,2,2-trifluoroethane (compound
    one)
    The results are shown 25 in the table.5 o
    Table5
    20
    50 In another experiment, N-chloroacetyl-N-methoxymethyl-2,6-diethylanilit1 is used as a herbicide, and 1- (A-chlorophenyl) -1- (1,3-dioxanol-2-yl- methoxyimino) -2, 2.2135 trifluoroethane. The experiment was carried out with the seeds of millet cultivar Funk G 522 (without weeds),
    The results are shown in Table 6 o.
     9 Table 6
    Example 6 with. Experience with antidote and herbicide on soy. Treatment with herbicide and antidote as a mixture until germination occurs.
    The diameter of the pots in the upper part of 6 cm is filled with sandy alumina, after which Khark seeds are sown. After the seeds are coated on the soil surface, it is applied by spraying the mixture of the substance and herbicide tested as anthondot in the form of a dilute solution. After 21 cj T after the treatment with the herbicide, the percentage of the antidote is evaluated as a percentage. only a herbicide, as well as untreated (control) plants.


    4-am - but 6-tert-booths - 4 (, 5-dihydro-3-methclthio-1a2,4-triazinon-5 (Metribuzin) is used as a herbicide;
    The resulting 1-; 1st results are presented in 5fbi table. 7 o
    Table;
    25
    zo Experience
    56958 5
    Example, Experience with antidote and herbicide on wheat. Treatment with herbicide and antidote after emergence when using the mixture,
    Seeds of wheat varieties Farnese are sown in a greenhouse in plastic pots (11 cm in diameter in the upper part, which contain 0.5 liter of soil). After covering the seeds and sprouting, they are treated with a mixture of BenjecTBa, tested as an antidote and bicide ( in the form of a mixture prepared in a container), 20 days 15 after treatment, the protective effect of the antidote is assessed in percent. For comparison, plants treated only with a herbicide and also untreated 2Q plants (control) plants are used
    As a herbicide, L-t4- (2,4-dichpro-pyridyl-2-oxyphene propiopic acid) propargyl ester is used.
    The data obtained are presented in tablobo
    Tables
    PRI me R 8, Experience with the antidote herbicide on rice. The use of an antidote in Bpet-w swelling of rice seeds, the use of a herbicide on moist soil before germination,
    Rice seeds for 48 hours are treated with a solution of a substance tested as an antidote with a concentration of 100. Directly thereafter, the seeds for
    55
      2 hours dried so that they are not sticky. Plastic containers (length 25 cm, ceirin 17 cm and height i2 cm) 2 cm below the edges are filled with sandy clay. Pre-nabu: - the largest seeds are sown on top11
    soil in containers and covered with a thin layer of soil. Then a herbicide in the form of a diluted solution is applied to the soil surface by spraying. The water level is gradually increased in accordance with growth. Eighteen days after the application of the herbicide, the protective effect is evaluated against the percentage, - For this, dl. comparisons use plants treated only with a herbicide, as well as untreated (control) plants.
    As a herbicide used 2-chloro-2, 6-diztil-N- (2-propyloxyethyl) -acetamide (Pretylachlor)
    The obtained data are presented in the table.
    Table9
    100
    0.25
    25
    Example 9: Experience with antidote and herbicide on rice ,. The use of antidote as a mordant for seeds. Application of herbicide on moist soil before germination
    In a glass vessel, rice seeds are mixed with a substance tested as an antidote. The seeds and product are thoroughly mixed by shaking and rotating the vessel. The containers (length 47 cm, width 29 cm, height 24 cm) are then filled with sandy alumina, after which the pickled seeds are sown. After the seeds are coated, a diluted herbicide solution is applied to the soil surface by spraying. Approximately 20 days after sowing (rice plants in the three-leaf stage), the soil surface is covered with a 4 cm high water layer. 30 days after the herbicide is applied, the protective effect of the antidote is assessed in percent. In this case, plants treated only with a herbicide, as well as untreated (control) plants, are used for comparison.
    2,6-dinitro-N, L-dipropyl-4-trifluoro-methylaniline (Trifluralin) is used as a herbicide.
     2
    data is presented in
    Table 10
    ten
    15
    As a herbicide use
    alpha-4- (2,4-dichlorophenoxy) phenoxy propionic acid methyl ester (Joelon)
    The data obtained are given in table. eleven
    Table 11
    thirty
    35
    40
    45
    Alpha-4- (2,4,4-dichloropyridyl-2 -oxyphenoxy propionic acid) propargyl ester is used as a herbicide.
    The data obtained are given in table. 12 o
    Table 12
    50
    55
    This method, by its antidote activity, is known.
    So, with a consumption rate of 0.4 kg / ha, the compound provides the same antidote effect as the known cyanoxime with a consumption rate of 1.5 kg / g (field tests on corn and millet and treatment with herbicides of the acetanilide range)
    Millet seeds treated with compound 1 have increased germination and are resistant to fungal infections.
    Field tests of the antidote activity of the compounds of formula (1)
    Two crops of millet were sown on six small equal-sized areas of open ground. Some time after sowing, three plots were treated with the herbicide — N-chloroacetanilide N- (2-methoxy-1-methyl) -2-ethyl-6-methylaniline (Metochlor) —from the calculation of 1.5 kg / ha, the other three The plot was treated with another herbicide — 2-chloro-2, 6-diethyl-N- (2-propyloxy-istil) -acetanilide (pre-chloro) at a rate of 2 kg / ha. Then, one site from these two fields was treated with the compound obtained by the proposed method in Example 1, three other sites were sprayed with antidotes at the optimum concentrations established in the previous experiments.
    In all areas, millet showed good growth with complete suppression of weeds or their partial germination. The compounds obtained by the proposed method with a lower consumption rate provide the same protective effect against the phtotoxic effect of chloroacetanilides, as is well known: - antideta.
    Effect on seed germination when applied to the seed coat
    Milk seeds of Funk type G 522 DR and DK 42 U were coated with an antidote substance, 4 Then they determined the ability of such seeds to germinate in comparison with the untreated seeds, which were then placed 50 cm of a thick layer of moist filter paper into Petri dishes and placed until the occurrence of the roots of the seeds of millet were kept in climatic chambers at 12 h light day, relative humidity of 20-90% and at temperature
    five
    botanical seeds germinated between 3 and 6 days, processed later — from the 7th day on. Evaluation was carried out 2 days later and expressed as a percentage of the table, 13
    As follows from the table (, 13, treatment with the compounds of examples 1 and 2 less inhibits the germination of weakly germinating seeds as compared with the known compounds.
    Protective action against fungal infection
    Millet seeds such as Tonxang and Teu 44R were treated as described. They were then tested for resistance to Sorg hurabawny mildew fungus and were compared with untreated seeds. Sown The cups were filled with sterile garden soil, which was sprayed with a suspension of Sorghumdawnymildew spores. The cups were kept for three days in a climate chamber at 12 hours light 5 days at 20 ° C day and night at 40-60% relative humidity. Then, 25 seeds of millet were sown in each sowing cup to a depth of 9 mm. Sowing cups were placed again in climatic chambers under the same conditions with regular irrigation with water, while monitoring the germination of seeds and killing dead plants. Fungi-affected plants were counted after 28 days. I was expressed as a percentage relative to the planted ones (Table 14) .J.
    Millet is treated with compounds obtained according to the proposed method and is more resistant to fungal injury as compared with known compounds.
    The compounds of formula (1) are low toxic compounds. So DL, pDl of the compound of example 1 is 0
    five
    0
    lt 4560 mg / kg
    T a b l
    and c
    13
     1356958
    Continuation of table 13
    Example 2 Treated with Compound I, 5 kg / ha
    example 3 European patent No. 11047
    Untreated 9.1
    Treated with compound (0.5 kg / ha)
    of example i 11,0
    example 2
    10.4
    Treated with the compound (1.5 kg / ha) of Example 3 (European Patent No. 11047)
    example 60. (European patent number 11047)
    sixteen
    Continuation of table 13
    ten
    Table 14
    16.4
    57
    15.7 16.2
    55
    58
    21.1
    55
    20.4
    66
    17
    权利要求:
    Claims (1)
    [1]
    Invention Formula
    Method for producing oximes of general formula (1)
    .c-x
    H
    R, KO-CH -SNSor
    where R J and R, j are hydrogen or halogen; R „and R. - jointly C –C alkylene; X - fluorinated C, -C „alkyl,
    characterized in that the salt of oxime of the General formula)
    Compiler V. Volkova Editor M. Petrova Tehred LoSerdyukova
    Order 5817/53. Circulation. 372 Subscription
    VNIIPI Gosz of the Soviet Union
    on affairs izoret .-, 5th and discoveries 113035, Moscow, ZH-ZZ Raushsk nab ,, d, 4/5
    Production Polygraphic Plant, Uzhgorod, Proektna St., 4
    R
    18
    F / II R N-OM
    where R, R x have the indicated meanings;
    M is an alkali metal cation, is reacted with a hapoid-ketal of the general formula
    /about
    Na1-CH2-CH
    where K and R have the indicated meanings; Hal - halogen,
    in an inert solvent or diluent
    Proofreader A.T. sko
    类似技术:
    公开号 | 公开日 | 专利标题
    DE2808317C2|1991-05-08|
    KR870001792B1|1987-10-12|Process for preparing optical isomer of triazolylpentenols
    US4220464A|1980-09-02|Phenylglyoxylonitrile-2-oxime-cyanomethyl ether as plant growth regulator
    RU2165144C1|2001-04-20|Fungicide composition, method of control of plant disease
    SU1356958A3|1987-11-30|Method of producing oximes
    SU1428196A3|1988-09-30|Method of producing 2-substituted phenyl-4,5,6,7-tetrahydro-2h-isoindole-1,3-dions
    HU182942B|1984-03-28|Antidote and herbicide compositions containing oxyme derivatives and process for preparing the antidote
    CS208796B2|1981-09-15|Fungicide means and means for regulation of the plant's growth and method of making the active substances
    PL132245B1|1985-02-28|Agent for controlling and/or protection against paralysis by harmfuk microorganisms and method of manufacture of novel derivatives of arylamines
    KR850000338B1|1985-03-21|Process for the acylated naphthylamines
    US4062962A|1977-12-13|Substituted pyridines as systemic plant protectants
    US3978228A|1976-08-31|Method for killing noxious fungi in plants using dihalo sulfonates
    KR860002107B1|1986-11-26|Process for the preparation of alpha,alpha-dimethylphenyl acetanilide
    CS208666B2|1981-09-15|Herbicide means and means for regulation of the plants growth
    RU2076603C1|1997-04-10|Method of agriculture crop productivity increase
    US4066760A|1978-01-03|Agricultural and horticultural fungicidal compositions
    US4039675A|1977-08-02|α,α-Dialkyl-substituted 3-pyridinemethanols as fungicidal agents
    SU519109A3|1976-06-25|Fungicidal agent
    AU595269B2|1990-03-29|Plant growth promotion
    IL45751A|1977-08-31|Benzimidazole-1-carboximidic acid esters process for their preparation and their use
    HU9702354A2|1998-09-28|Method to control plant fungal diseases
    US4228101A|1980-10-14|Two dichloroacetamide antidotes for non-selective herbicides particularly active in the protection of maize against the poisonous action exerted by herbicides esters of N,N-disubstituted glycine
    SU715006A1|1980-02-05|Fungicidic nematocidic agent
    JP3624209B2|2005-03-02|Agricultural and horticultural fungicides
    KR100231518B1|1999-11-15|Fungicidal compositions for agricultural and horticultural use
    同族专利:
    公开号 | 公开日
    JPS58170745A|1983-10-07|
    ES8500222A1|1984-11-01|
    EP0089313A1|1983-09-21|
    CA1205477A|1986-06-03|
    OA07341A|1984-08-31|
    IL68121A|1986-11-30|
    DE3360154D1|1985-06-05|
    PT76384B|1986-02-03|
    RO86646A|1985-04-17|
    HU191606B|1987-03-30|
    US4530716A|1985-07-23|
    RO86646B|1985-05-03|
    MY8700807A|1987-12-31|
    IL68121D0|1983-06-15|
    AR241243A1|1992-03-31|
    AT13053T|1985-05-15|
    GR77161B|1984-09-10|
    US4707182A|1987-11-17|
    LV10149A|1994-10-20|
    BR8301263A|1983-11-22|
    JPH0124140B2|1989-05-10|
    US4576628A|1986-03-18|
    ZA831735B|1983-12-28|
    ES520579A0|1984-11-01|
    PT76384A|1983-04-01|
    MX157788A|1988-12-15|
    EP0089313B1|1985-05-02|
    CS235315B2|1985-05-15|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    CH632130A5|1977-03-02|1982-09-30|Ciba Geigy Ag|Compositions on the basis of oxime ethers, oxime esters or oxime carbamates which are suitable in agriculture for crop protection|
    IT1110460B|1977-03-02|1985-12-23|Ciba Geigy Ag|PRODUCTS THAT PROMOTE THE GROWTH OF PLANTS AND PRODUCTS THAT PROTECT PLANTS BASED ON BODY ETHERS AND BODY ESTERS THEIR PREPARATION AND USE|
    US4269775A|1978-09-01|1981-05-26|Ciba-Geigy Corporation|Oxime derivatives for protecting plant crops|
    US4347372A|1978-09-01|1982-08-31|Ciba-Geigy Corporation|Benzoxazolyl-glyoxylonitrile-2-oxime ether derivatives|
    DE3360154D1|1982-03-15|1985-06-05|Ciba Geigy Ag|Oxime ethers, process for their preparation, compositions containing the oxime ethers and their use|
    EP0092517B1|1982-04-16|1986-03-12|Ciba-Geigy Ag|Oxime ethers, process for their preparation, agents containing these compounds and their use|DE3360154D1|1982-03-15|1985-06-05|Ciba Geigy Ag|Oxime ethers, process for their preparation, compositions containing the oxime ethers and their use|
    EP0092517B1|1982-04-16|1986-03-12|Ciba-Geigy Ag|Oxime ethers, process for their preparation, agents containing these compounds and their use|
    DE3481031D1|1983-04-12|1990-02-22|Ciba Geigy Ag|HERBICIDAL AGENT.|
    IL75858A|1984-07-31|1989-02-28|Commw Scient Ind Res Org|Substituted benzyl ethers of oximes,their production and their use as arthropodicides|
    US5201933A|1988-08-01|1993-04-13|Monsanto Company|Safening herbicidal benzoic acid derivatives|
    DE4014171A1|1990-05-03|1991-11-07|Basf Ag|cyanoquinoline|
    US5266726A|1990-10-22|1993-11-30|Ciba-Geigy Corporation|Sterically hindered oxime color improvers for polyolefin processing|
    US5134183A|1990-10-22|1992-07-28|Ciba-Geigy Corporation|Sterically hindered oxime color improvers for polyolefin processing|
    US5541148A|1992-07-08|1996-07-30|Ciba-Geigy Corporation|Selective safened herbicidal composition comprising 2-ethoxycarbonyl-3- oxy-pyridine and an acylsulfamoylphenyl-urea safener|
    US6342466B1|1999-09-02|2002-01-29|Clariant FinanceLimited|Biodegradable solutions of biologically active compounds|
    CN109938042B|2019-04-25|2021-04-27|河北省农林科学院谷子研究所|Seed coating agent for chemical weeding in sorghum field and weeding method|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    CH160982|1982-03-15|LTRP1277A| LT2606B|1982-03-15|1993-09-29|THE BIRTH OF OXYMUS RECEIVING|
    [返回顶部]